Efficacy of Post-contracture Release Radiation for the Treatment of Dupuytren's Disease

What this Trial Is About

Researchers are evaluating the treatment pathway for Dupuytren's Disease, specifically looking at the combination of contracture release treatments followed by radiation therapy. This observational pilot study aims to provide scientific evidence supporting the clinical impression that patients improve with this current treatment approach. The study is sponsored by the University of Minnesota and focuses on assessing patient outcomes over time using established scoring systems. Participants will receive standard care for Dupuytren's Disease, which includes contracture release procedures such as limited fasciectomy, percutaneous needle aponeurotomy (PNA), and collagenase Clostridium histolyticum (CCH) injections. Following surgery, they will undergo radiation therapy consisting of two courses: five daily treatments of 300 cGy to the palm, a 6-8 week break, then a second five-day course of 300 cGy, totaling 3000 cGy in 10 fractions. This dosing follows commonly used schedules documented in medical literature. Throughout the study, participants' condition will be monitored through the Southampton Dupuytren's score, clinical history, symptom tracking, and hand photographs. Assessments occur at baseline before surgery, during radiation planning, about six weeks after completing radiation, and again at one and two years post-radiotherapy. Researchers will also monitor adverse events using recognized criteria over two years. The study involves no additional interventions beyond standard care and collects patient-reported outcomes and medical record data to evaluate long-term effectiveness and safety.

Post-contracture Release Radiation for Dupuytren's Disease