Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury Observational Study

What this Trial Is About

Researchers are studying the ability of certain respiratory muscle and central drive measurements to predict successful removal from mechanical ventilation in patients with traumatic brain injury. The focus is on maximal inspiratory pressure (PImax), airway occlusion pressure (P0.1), and their ratio, to see how well these values forecast breathing success after extubation. This observational study involves patients who have been intubated and on mechanical ventilation for more than 24 hours in an intensive care setting. Measurements will be taken before spontaneous breathing trials, including a 20-second assessment of PImax, P0.1, and their ratio using specialized devices attached to the airway. Patients will be monitored closely during these tests to ensure safety, with specific criteria to stop the trial if signs of distress appear. If patients pass the breathing trial without deterioration, they will be extubated and receive oxygen support through a Venturi mask. Participants will be monitored continuously during the study with pulse oximetry and electrocardiogram and attended by respiratory physiotherapists. The main outcome measured is the accuracy of the respiratory parameters in predicting successful weaning from mechanical ventilation, defined as sustaining spontaneous breathing for 48 hours post-extubation. The study period includes measurements during breathing trials and follow-up for at least 48 hours after ventilator withdrawal.

Predictive Value of Airway Occlusion Pressure, Maximal Inspiratory Pressure and Their Ratio for Successful Extubation in Patients With Traumatic Brain Injury