Study of the ZyMôt Sperm Selection Method and Its Effect on Embryo Ploidy

What this Trial Is About

Researchers are studying male infertility by evaluating a new sperm selection device called the ZyMôt chip. This chip aims to recover sperm with lower DNA fragmentation, which has been linked to reduced fertilization rates and embryo development. The study compares this new microfluidic device to the conventional swim-up sperm selection method, exploring its impact on embryo chromosomal normality (euploidy rate) and examining molecular effects related to sperm DNA quality in couples facing infertility challenges such as unexplained infertility, recurrent pregnancy loss, or varicocele. The trial processes semen samples from male participants using two methods: half of each sample is treated with the routine swim-up technique involving centrifugation and incubation, and the other half is processed using the ZyMôt sperm separation chip, which filters sperm based on motility without centrifugation. The device incubates the sample at body temperature for up to 30 minutes, allowing selection of sperm with better motility. Both methods are then compared for their effects on sperm and reproductive outcomes. Participants undergo assessments including sperm mobility, vitality, DNA fragmentation, retrieval rates, fertilization success, and blastocyst usefulness over one year. Embryos are monitored in a time-lapse incubator, and molecular analyses investigate sperm DNA effects on oocytes with limited repair capacity. The study tracks these outcomes to assess whether the ZyMôt device improves sperm quality and embryo development compared to traditional methods, with the total participation spanning about one year.

Study of the ZyMōt Sperm Selection Method and Its Effect on Embryo Ploidy.