Actively Recruiting
Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients
Led by Chulalongkorn University · Updated on 2026-05-07
46
Participants Needed
1
Research Sites
63 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients. All participants must have an indwelling arterial catheter for continuous hemodynamic monitoring.
CONDITIONS
Official Title
Using a Hypotension Prediction Index to Prevent Low Blood Pressure During Dialysis in ICU Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults >18 years old
- Diagnosed with acute kidney injury (AKI) or end-stage kidney disease (ESKD)
- Admitted to medical intensive care unit (ICU)
- Scheduled for prolonged intermittent renal replacement therapy (PIRRT)
- Have an indwelling arterial catheter for continuous monitoring
You will not qualify if you...
- Severe right heart dysfunction
- Significant valvular disease
- Arrhythmias
- Mechanical circulatory support
- Absence of arterial access
- No ultrafiltration (UF) prescription
- Receiving palliative care
- Expected ICU stay less than 72 hours
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Division of Nephrology, Faculty of Medicine, Chulalongkorn University
Bangkok, Thailand
Actively Recruiting
Research Team
N
Nattapakorn Mai-on
CONTACT
N
Nuttha Lumlertgul
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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