Sleeve Gastrectomy and OverStitch17 Endoscopic Suturing System in the Modulation of Perceived Satiety

What this Trial Is About

Researchers are studying how perceived satiety, or the feeling of fullness, changes after two types of bariatric surgery in adults with severe obesity. The study focuses on patients who are candidates for Sleeve Gastrectomy or those needing revision surgery with the OverStitch17 Endoscopic Suturing System due to weight regain after prior bariatric surgery. This research explores how surgical changes affect hunger and fullness using a non-invasive test since current data on satiety in patients with gastro-jejunal anastomosis dilation is limited. Participants will undergo either Sleeve Gastrectomy, which involves removing a large part of the stomach to create a smaller, tube-shaped stomach, or a revision surgery using the OverStitch17 Endoscopic Suturing System. The latter is a fully endoscopic method that tightens the enlarged gastro-jejunal connection to reduce complications and improve satiety. Both procedures aim to modify gastric function to influence hunger and fullness. During the study, participants will have their satiety measured using the Water Load Test before surgery and again six months afterward. This test measures how much water a person drinks until feeling pleasantly full, reflecting their subjective satiety. Researchers will monitor changes in satiety to assess the impact of the surgeries. The total monitoring period spans at least six months post-procedure to evaluate sustained effects on hunger and fullness.

Bariatric Surgery and Modulation of Perceived Satiety