Actively Recruiting
Bariatric Surgery and Pharmacokinetics of Chlorprothixene: BAR-MEDS Chlorprothixene
Led by Norwegian University of Science and Technology · Updated on 2025-06-08
12
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Norwegian University of Science and Technology
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to understand how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the pharmacokinetics of chlorprothixene, a medication. Changes in stomach acidity, emptying time, and enzyme activity after surgery may influence how medicines are absorbed and processed in the body. Currently, little is known about these effects on chlorprothixene's availability in patients undergoing these surgeries. The study observes patients who are preparing for gastric bypass or sleeve gastrectomy in Central Norway and who are taking their regular prescribed chlorprothixene medication. It does not involve any new treatments but monitors the medication's concentration in the blood over time. The primary focus is on measuring chlorprothixene levels from before surgery up to one year after the operation. Participants will have their chlorprothixene blood serum levels measured to calculate the area under the curve (AUC), reflecting how much medication is available in their system. The study tracks these levels from baseline through one year post-surgery to assess changes. No additional treatments or interventions are given, and the study involves regular monitoring and blood tests over the course of the year.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Chlorprothixene
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
- Aged 18 to 70 years
You will not qualify if you...
- Having previously undergone resections in the GI-tract
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of surgery plus hospital stay
Participants undergo gastric bypass or sleeve gastrectomy surgery and immediate post-operative care.
1 surgical visit and hospital stay
Duration - Up to 1 year postoperatively
Participants are monitored for chlorprothixene concentration in blood serum from baseline to 1 year postoperatively.
Periodic visits for blood sampling up to 1 year
Trial Site Locations
Total: 1 location
1
St. Olavs University Hospital
Trondheim, Norway
Actively Recruiting
Research Team
M
Magnus Strømmen, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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