Actively Recruiting
Study of How Gastric Bypass and Sleeve Gastrectomy Affect Chlorprothixene Medicine Levels in Adults with Morbid Obesity
Led by Norwegian University of Science and Technology · Updated on 2026-07-08
12
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
This research aims to understand how bariatric surgery, including gastric bypass and sleeve gastrectomy, affects the way the body processes the medication chlorprothixene. Changes in stomach acidity, emptying time, and enzyme activity after surgery may influence medicine absorption, but little is known about these effects specifically for chlorprothixene. Participants in this observational study take their usual prescribed chlorprothixene medication before and after surgery. The study monitors how the surgery impacts the drugs presence in the bloodstream over time, focusing on changes from before surgery to one year afterward. During the study, participants will have their blood tested to measure chlorprothixene levels, tracking the area under the curve AUC from baseline to one year post-operation. The study is sponsored by the Norwegian University of Science and Technology and is expected to continue through December 2026, involving adults preparing for bariatric surgery in Central Norway.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Chlorprothixene
Research Team
M
Magnus Strømmen, MSc
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