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Study of How Gastric Bypass and Sleeve Gastrectomy Affect Amlodipine Medication in Adults with Severe Obesity
Led by Norwegian University of Science and Technology · Updated on 2025-06-06
12
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are exploring how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body processes the medication amlodipine in people with morbid obesity. This observational study aims to better understand changes in stomach acidity, emptying time, and enzyme activity that might influence the absorption and availability of amlodipine after surgery. Participants in this study are patients preparing for gastric bypass or sleeve gastrectomy in Central Norway who are currently prescribed amlodipine. Researchers will observe and measure the concentration of amlodipine in the blood serum over time, focusing on changes from before surgery up to one year after the procedure. During the study, participants will have their usual amlodipine medication monitored through blood tests to assess how the surgery impacts the drugs levels. The main measurement is the area under the curve AUC of amlodipine concentration in the blood serum. The study runs from the start date in November 2016 and will continue until May 2026, allowing for long-term observation of medication changes post-surgery.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Amlodipine
Research Team
M
Magnus Strømmen, MSc
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