Actively Recruiting
Bariatric Surgery and Pharmacokinetics Amlodipine: BAR-MEDS Amlodipine
Led by Norwegian University of Science and Technology · Updated on 2025-06-06
12
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Norwegian University of Science and Technology
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are exploring how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body processes the medication amlodipine in people with morbid obesity. This observational study aims to better understand changes in stomach acidity, emptying time, and enzyme activity that might influence the absorption and availability of amlodipine after surgery. Participants in this study are patients preparing for gastric bypass or sleeve gastrectomy in Central Norway who are currently prescribed amlodipine. Researchers will observe and measure the concentration of amlodipine in the blood serum over time, focusing on changes from before surgery up to one year after the procedure. During the study, participants will have their usual amlodipine medication monitored through blood tests to assess how the surgery impacts the drug's levels. The main measurement is the area under the curve (AUC) of amlodipine concentration in the blood serum. The study runs from the start date in November 2016 and will continue until May 2026, allowing for long-term observation of medication changes post-surgery.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Amlodipine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
- Age between 18 and 70 years
You will not qualify if you...
- Having previously undergone resections in the gastrointestinal tract (GI-tract surgery removing parts of the digestive system prior to this study participation)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 week or until discharge
Participants undergo bariatric surgery including gastric bypass or sleeve gastrectomy and receive immediate post-operative care.
1 surgical visit and immediate post-operative assessments
Duration - Up to 1 year
Participants are monitored for blood levels of amlodipine and recovery progress for up to 1 year after surgery.
Periodic blood sampling visits during follow-up
Trial Site Locations
Total: 1 location
1
St. Olavs University Hospital
Trondheim, Norway
Actively Recruiting
Research Team
M
Magnus Strømmen, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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