Effects of Gastric Bypass and Sleeve Gastrectomy on Buprenorphine Medication in Adults with Morbid Obesity

What this Trial Is About

This research aims to understand how bariatric surgery, including gastric bypass and sleeve gastrectomy, affects the way buprenorphine medication is absorbed and processed in the body. The study focuses on individuals with morbid obesity who are preparing for these types of weight-loss surgeries. It investigates changes in stomach pH, gastric emptying time, and enzyme activity that may influence medication availability after surgery. Participants who are preparing to undergo gastric bypass or sleeve gastrectomy will have their usual buprenorphine medication monitored. The study observes how the pharmacokinetics of buprenorphine change from before surgery up to one year after the operation. This is an observational study without additional treatments or interventions beyond the participants standard care. During the study, researchers will measure buprenorphine concentration in the blood serum through specific tests, focusing on the area under the curve AUC from baseline to one year post-surgery. Participants will be followed for up to one year to assess medication changes over time. The study is sponsored by the Norwegian University of Science and Technology and involves regular monitoring to understand medication absorption after bariatric surgery.

Bariatric Surgery and Pharmacokinetics of Buprenorphine