Study of How Gastric Bypass and Sleeve Gastrectomy Affect the Medicine Candesartan in Adults with Severe Obesity

What this Trial Is About

This research aims to understand how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the way the body processes the medication candesartan. These surgeries may change factors like stomach acid levels, emptying time, and enzyme activity, which can influence drug absorption and availability. The study focuses on patients with morbid obesity undergoing these surgeries in Central Norway. Participants in this observational study are people preparing for gastric bypass or sleeve gastrectomy. Researchers will observe how their usual candesartan medication is processed before and up to one year after surgery. No additional treatments or drugs are administered as part of the study, as it monitors the natural effects of surgery on medication levels. Throughout the study, participants will have their blood serum candesartan concentration measured from baseline to one year postoperatively. These measurements help evaluate how surgery impacts candesartans biological availability. Participants medical history and surgery details will be recorded, and follow-up assessments will take place up to one year after surgery to track changes over time.

Bariatric Surgery and Pharmacokinetics of Candesartan