Actively Recruiting
Bariatric Surgery and Pharmacokinetics Candesartan: BAR-MEDS Candesartan
Led by Norwegian University of Science and Technology · Updated on 2025-06-06
12
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Norwegian University of Science and Technology
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the way the body processes the medicine candesartan. The study focuses on changes in stomach acidity, emptying time, and enzyme activity that may alter the medication's availability in patients with morbid obesity. This observational study aims to better understand these effects to inform treatment after surgery. Participants in this study are people preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway. They continue their usual candesartan medication as prescribed, and researchers observe how the surgery impacts the drug's concentration in the blood. The study tracks these changes from before surgery up to one year after the operation. During the study, participants will have their blood tested to measure candesartan levels at various times from baseline through one year post-surgery. This helps determine how the surgery affects the medication's presence in the body over time. The involvement includes regular follow-ups and monitoring to collect this information, with the total participation lasting about one year after surgery.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Candesartan
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
- Aged between 18 and 70 years
You will not qualify if you...
- Having previously undergone resections in the gastrointestinal tract
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Hospital stay plus initial recovery period
Participants undergo bariatric surgery including gastric bypass or sleeve gastrectomy and receive immediate post-operative care.
1 surgery visit and several in-hospital care visits
Duration - Up to 1 year postoperatively
Participants are monitored for up to 1 year postoperatively to assess candesartan concentration in blood serum.
Periodic blood sample visits over 1 year
Trial Site Locations
Total: 1 location
1
St. Olavs University Hospital
Trondheim, Norway
Actively Recruiting
Research Team
M
Magnus Strømmen, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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