Actively Recruiting
Studying How Gastric Bypass and Sleeve Gastrectomy Affect Enalapril Medication in Adults with Severe Obesity
Led by Norwegian University of Science and Technology · Updated on 2026-07-08
12
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are investigating how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the way the body absorbs and processes the medication enalapril. This study focuses on understanding changes in gastric pH, gastric emptying time, gastrointestinal transit time, and enzyme activity in the gut mucosa, which may influence how enalapril is metabolized in people with morbid obesity. Participants preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway will be observed while taking their usual prescribed enalapril medication. The study tracks how enalapril concentration in blood serum changes from before surgery to one year after the operation, without introducing new treatments or medications. During the study, participants will have their enalapril blood levels measured at various times to assess pharmacokinetic changes. The main outcome measured is the area under the curve AUC of enalapril concentration in blood serum from baseline up to one year after surgery. The study spans over several years, with follow-up assessments up to one year postoperatively.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Enalapril
Research Team
M
Magnus Strømmen, MSc
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