Actively Recruiting
Bariatric Surgery and Pharmacokinetics Enalapril: BAR-MEDS Enalapril
Led by Norwegian University of Science and Technology · Updated on 2025-06-06
12
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Norwegian University of Science and Technology
Lead Sponsor
S
St. Olavs Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how bariatric surgery, such as gastric bypass and sleeve gastrectomy, affects the way the body absorbs and processes the medication enalapril. Changes in stomach acidity, emptying time, and enzyme activity can alter how medicines work, but little is known about these effects after bariatric surgery. This observational study aims to understand these pharmacokinetic changes in patients with morbid obesity. Participants in this study are patients preparing for gastric bypass or sleeve gastrectomy surgery in Central Norway. Their usual enalapril medication levels will be tested before and after surgery to observe how the surgery changes the medication's availability in the blood. The study focuses on measuring enalapril concentration over time from baseline up to one year after surgery. During the study, participants will have blood serum tests to measure enalapril concentration, focusing on the area under the curve (AUC) from before surgery until one year afterward. Researchers will monitor how the drug is processed in the body after surgery to understand changes in medication absorption. The total study period for each participant spans from pre-surgery through a one-year postoperative follow-up.
CONDITIONS
Brief Title
Bariatric Surgery and Pharmacokinetics of Enalapril
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway
- Being a Norwegian citizen
- Aged between 18 and 70 years
You will not qualify if you...
- Having previously undergone resections in the gastrointestinal tract
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 1 week
Participants undergo bariatric surgery and immediate post-operative care.
1 surgery visit and several immediate post-operative visits (in-person)
Duration - Up to 1 year
Participants are monitored for enalapril concentration in blood serum from baseline to 1 year postoperatively.
Periodic visits for blood sample collection up to 1 year postoperatively
Trial Site Locations
Total: 1 location
1
St. Olavs University Hospital
Trondheim, Norway
Actively Recruiting
Research Team
M
Magnus Strømmen, MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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