Study of Fluoxetine Medication Effects in Adults Undergoing Gastric Bypass or Sleeve Gastrectomy for Severe Obesity

What this Trial Is About

This research aims to understand how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the way the body processes the medication fluoxetine. The study focuses on changes in stomach acidity, emptying time, and digestive transit that may alter fluoxetines absorption and metabolism in patients with morbid obesity. The investigation seeks to fill gaps in knowledge about medication availability after these surgeries. Participants in this observational study are individuals preparing for gastric bypass or sleeve gastrectomy in Central Norway and currently taking fluoxetine as prescribed. The study observes and measures fluoxetine concentration in blood serum from before surgery through one year after the operation, without altering their prescribed medication regimen. During the study, participants fluoxetine levels are monitored at various points up to one year post-surgery. Researchers collect blood samples to assess the area under the curve AUC for fluoxetine concentration, providing insight into the medications pharmacokinetics after bariatric procedures. The study involves regular follow-up to understand long-term effects on drug absorption and metabolism.

Bariatric Surgery and Pharmacokinetics of Fluoxetine