Study of How Bariatric Surgery Affects the Blood Levels of Escitalopram in Adults With Morbid Obesity

What this Trial Is About

Researchers are investigating how bariatric surgery, such as gastric bypass or sleeve gastrectomy, affects the way the body processes the medication escitalopram. This study focuses on understanding changes in drug absorption and metabolism caused by surgical alterations to the stomach and digestive system in adults with morbid obesity. The goal is to learn how these surgeries impact the blood levels of escitalopram over time. Participants in this observational study include adults preparing for bariatric surgery in Central Norway who are currently taking escitalopram as prescribed. The study tracks escitalopram concentration in blood serum from before surgery up to one year afterward. There are no treatment groups or placebo controls, as the study observes natural changes in medication levels related to the surgery. Throughout the study, participants have their blood tested to measure escitalopram concentration at multiple points from baseline to one year after surgery. Researchers monitor how the surgery influences drug availability and metabolism. The total participation period spans about one year postoperatively, with assessments focused on pharmacokinetic changes related to the surgical procedures.

Bariatric Surgery and Pharmacokinetics of Escitalopram