Spontaneous coronary artery dissection: a disease-specific, social networking community-initiated study.
Marysia S Tweet, Rajiv Gulati, Lee A Aase...
https://pubmed.ncbi.nlm.nih.gov/21878595Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID01427179
Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Led by Mayo Clinic · Updated on 2026-04-15
2000
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the genetic causes of spontaneous coronary artery dissection (SCAD), a condition involving tears in the heart's blood vessels. This study aims to identify inherited and new mutations that may cause or increase the risk of SCAD. The research includes adults diagnosed with SCAD, as well as their biological parents and relatives with related artery conditions like fibromuscular dysplasia and arterial aneurysm. The study involves collecting blood or saliva samples to create a biobank of genomic DNA and plasma from people with SCAD. Confirmation of SCAD diagnosis through coronary angiography review is required before enrollment. Both retrospective and prospective participants will be included to help identify genetic mutations responsible for SCAD and common genetic variants that may increase susceptibility. Participants will provide informed consent and complete a questionnaire. Researchers will review participants' coronary angiography images and collect genetic samples for analysis. The main outcome measure is identifying one or more gene mutations linked to SCAD by the end of the study. The trial is observational, with no treatment interventions, and participation involves genetic testing and data collection procedures.
CONDITIONS
Brief Title
Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Men and women able to give informed consent and complete a 2 page questionnaire
- Diagnosis of one or more episodes of spontaneous coronary artery dissection (SCAD)
- Biological parent of individual with SCAD
- Relative with fibromuscular dysplasia, arterial aneurysm, or arterial dissection
You will not qualify if you...
- Lack of confirmation of SCAD diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Sample Collection
Duration - Up to several months depending on enrollment timing
Participants provide blood or saliva samples for genetic analysis and complete a questionnaire. Biological relatives may also provide samples depending on their eligibility.
1 to 2 visits depending on family member involvement
Long-term Monitoring
Duration - Up to study completion in December 2030
Participants are observed over time to support genetic research and biomarker development related to spontaneous coronary artery dissection (SCAD).
Visits as needed for sample collection and assessments
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
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Research Team
J
Jake Nemgar
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association.
Sharonne N Hayes, Esther S H Kim, Jacqueline Saw...
https://pubmed.ncbi.nlm.nih.gov/29472380Spontaneous coronary artery dissection and its association with heritable connective tissue disorders.
Stanislav Henkin, Sara M Negrotto, Marysia S Tweet...
https://pubmed.ncbi.nlm.nih.gov/26864667Familial spontaneous coronary artery dissection: evidence for genetic susceptibility.
Kashish Goel, Marysia Tweet, Timothy M Olson...
https://pubmed.ncbi.nlm.nih.gov/25798899Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection.
David Adlam, Timothy M Olson, Nicolas Combaret...
https://pubmed.ncbi.nlm.nih.gov/30621952Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection.
Tamiel N Turley, Jeanne L Theis, Rhianna S Sundsbak...
https://pubmed.ncbi.nlm.nih.gov/30888838Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection.
Tamiel N Turley, Megan M O'Byrne, Matthew L Kosel...
https://pubmed.ncbi.nlm.nih.gov/32374345Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation.
David Adlam, Takiy-Eddine Berrandou, Adrien Georges...
https://pubmed.ncbi.nlm.nih.gov/37248441Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection.
Tamiel N Turley, Matthew L Kosel, William R Bamlet...
https://pubmed.ncbi.nlm.nih.gov/34384238Prevalence and Clinical Factors of Migraine in Patients With Spontaneous Coronary Artery Dissection.
Susan N Kok, Sharonne N Hayes, F Michael Cutrer...
https://pubmed.ncbi.nlm.nih.gov/30561271