Genetic Study to Identify Mutations Causing Spontaneous Coronary Artery Dissection SCAD

What this Trial Is About

Researchers are investigating the genetic causes of spontaneous coronary artery dissection SCAD, a condition involving tears in the hearts blood vessels. This study aims to identify inherited and new mutations that may cause or increase the risk of SCAD. The research includes adults diagnosed with SCAD, as well as their biological parents and relatives with related artery conditions like fibromuscular dysplasia and arterial aneurysm. The study involves collecting blood or saliva samples to create a biobank of genomic DNA and plasma from people with SCAD. Confirmation of SCAD diagnosis through coronary angiography review is required before enrollment. Both retrospective and prospective participants will be included to help identify genetic mutations responsible for SCAD and common genetic variants that may increase susceptibility. Participants will provide informed consent and complete a questionnaire. Researchers will review participants coronary angiography images and collect genetic samples for analysis. The main outcome measure is identifying one or more gene mutations linked to SCAD by the end of the study. The trial is observational, with no treatment interventions, and participation involves genetic testing and data collection procedures.

Genetic Investigations in Spontaneous Coronary Artery Dissection (SCAD)