Actively Recruiting
Cardiopulmonary, Hemodynamic, and Symptom Responses to Aerobic and Resistance Exercise in Patients with Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia
Led by Mayo Clinic · Updated on 2026-04-13
28
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating how people with Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD) respond to different types and intensities of aerobic and resistance exercise. This study aims to understand the effects on heart and lung function, blood flow, and symptoms during exercise in this group of patients. The trial is a single-center, single-arm prospective clinical trial sponsored by Mayo Clinic. Participants with a history of SCAD and/or FMD will complete three separate exercise tests spaced at least 48 hours apart. These tests include a symptom-limited cardiopulmonary exercise test on a cycle, two stages of submaximal constant power cycling at moderate and heavy intensity, and a series of six resistance exercises involving chest press, lateral raises, abdominal crunches, planks, leg press, and weighted lunges. The exercises are designed to study different intensities and types of physical activity. During the study visits, researchers will measure changes in blood pressure at multiple time points, assess functional status and physical activity levels using questionnaires like the Dartmouth COOP Functional Assessment Chart, Duke Activity Index Status, and International Physical Activity Questionnaire Short Form. They will also track perceived exertion and blood lactate levels before and during exercise. The study includes careful monitoring of participants' responses to exercise and lasts for the duration of the three test sessions.
CONDITIONS
Brief Title
A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of Spontaneous Coronary Artery Dissection (SCAD) and/or Fibromuscular Dysplasia (FMD), at least 2 months post-event and free from chest pain
- Able to provide written informed consent
- Aged between 21 and 65 years
You will not qualify if you...
- Clinically obese with a body mass index (BMI) of 36 or higher
- Musculoskeletal or other conditions limiting exercise participation
- Medically unstable individuals
- Unable to comply with study requirements
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Tests are separated by at least 48 hours
Participants undergo three exercise tests including a cardiopulmonary exercise test, submaximal constant power exercise test, and resistance exercises.
3 visits (in-person)
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
Research Team
A
Armia R. Habil, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
1
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