Actively Recruiting
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Led by University of Texas Southwestern Medical Center · Updated on 2025-02-24
24
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.
CONDITIONS
Official Title
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy male and female individuals
- Aged 18 to 35 years or 65 years and older
- Free of any underlying moderate to serious medical conditions
You will not qualify if you...
- Known heart disease or chronic medical conditions requiring regular treatment including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
- Taking medications affecting cardiac function or sweating responses such as beta blockers and non-dihydropyridine calcium channel blockers
- Abnormal findings on routine screening
- Current smokers or those who have regularly smoked in the past 3 years
- Body mass index greater than 30 kg/m²
- Pregnant individuals
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
Z
Zachary McKenna, PhD
CONTACT
T
Taysom Wallace, MS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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