Actively Recruiting
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Led by University of Texas Southwestern Medical Center · Updated on 2025-02-24
24
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
U
University of Texas Southwestern Medical Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how extreme heat affects heart blood flow and heart function in both young and older adults. This study focuses on understanding why older adults face higher risks of hospitalization and death during heat waves, mainly due to heart-related issues. The study aims to explore how aging impacts cardiovascular responses to heat stress by measuring myocardial blood flow and myocardial flow reserve. Participants will be exposed to a controlled 3-hour heat session set at 44°C with 20% humidity. The study includes two groups: young adults aged 18 to 39 years and older adults aged 65 years or older. Researchers will compare heart blood flow and heart function between these groups during and after heat exposure to assess how heat affects the heart differently by age. During the study, participants will undergo tests to measure heart blood flow and reserve at baseline and after the heat exposure. Additional assessments include core body temperature, heart rate, blood pressure, and heart ventricle function before, during, and after heat stress. The main outcomes focus on changes in myocardial flow reserve and myocardial blood flow related to heat exposure. The total participation involves these evaluations around the heat exposure period.
CONDITIONS
Brief Title
Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy male and female individuals
- Age 18 to 35 years or 65 years and older
- Free of any moderate to serious medical conditions
You will not qualify if you...
- Known heart disease or chronic conditions needing regular medical treatment such as cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled high cholesterol
- Taking medications that affect heart function or sweating, including beta blockers and certain calcium channel blockers
- Abnormal findings on routine screening
- Current smokers or those who smoked regularly within the past 3 years
- Body mass index over 30 kg/m²
- Pregnant individuals
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 3 hours
Participants undergo a 3-hour ambient heating session in 44°C and 20% relative humidity to assess myocardial blood flow and flow reserve.
1 visit (in-person)
Duration - Throughout the heat exposure visit
Measurements such as heart rate, blood pressure, core temperature, and ventricular function are collected before, during, and after heat exposure to monitor participant responses.
Continuous assessments during the 3-hour visit
Trial Site Locations
Total: 1 location
1
Texas Health Presbyterian Hospital Dallas
Dallas, Texas, United States, 75231
Actively Recruiting
Research Team
Z
Zachary McKenna, PhD
T
Taysom Wallace, MS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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