Slowly progressive aphasia without generalized dementia.
M M Mesulam
https://pubmed.ncbi.nlm.nih.gov/7114808Actively Recruiting
All Genders
ID00537004
Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia
Led by Northwestern University · Updated on 2026-02-27
500
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
N
Northwestern University
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The research investigates primary progressive aphasia (PPA), focusing on the neurological and language decline that occurs during the illness. The study aims to better understand behavioral, anatomical, and physiological changes in people with PPA, increase awareness of this unique disorder, educate others, and promote further research toward developing treatments. Participants join a three-day research program that includes neuropsychological testing, advanced brain imaging such as MRI and PET scans, cognitive experiments, and various computer and language tests. The study may ask participants to return every two years to repeat the same assessments. Travel and accommodations are provided for those living far from Chicago, Illinois. During the study, participants undergo thorough evaluations including cognitive tests and imaging scans. Researchers measure neuropsychological variables immediately after testing and again two years later to track changes. The study is observational, with no experimental treatments, and focuses on monitoring language and brain function over time.
CONDITIONS
Brief Title
Language in Primary Progressive Aphasia
Who Can Participate
All Genders
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary progressive aphasia
- Right-handed
- Native English speaker
- Visual acuity of 20/30 corrected
- Adequate hearing to follow conversation
- Safe for an MRI scan
You will not qualify if you...
- Left-handedness
- Claustrophobia
- Presence of significant medical illness that could interfere with participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - 3 days
Participants undergo neuropsychological testing, advanced imaging (MRI and PET), cognitive experiments, and language testing batteries during a three-day research program.
1 visit (in-person) lasting 3 days
Long-term Monitoring
Duration - Up to several years with assessments every 2 years
Participants may be asked to return every two years to complete the same assessments to monitor changes over time.
Follow-up visits every 2 years
Trial Site Locations
Total: 1 location
1
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
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Research Team
E
Elizabeth A Haynes
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features.
S Weintraub, N P Rubin, M M Mesulam
https://pubmed.ncbi.nlm.nih.gov/2252450Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia.
M-Marsel Mesulam, Christina Coventry, Alan Kuang...
https://pubmed.ncbi.nlm.nih.gov/33441454