Long-Term Brain Imaging Study to Track Changes in Progressive Apraxia of Speech and Related Language Disorders

What this Trial Is About

Researchers are investigating how changes in brain structure and function, seen through imaging, relate to the progression of speech, language, neurological, and psychological symptoms in people with neurodegenerative apraxia of speech AOS. This disorder affects speech production and may occur alone or alongside a type of language difficulty called non-fluent aphasia NFA. The study aims to understand disease progression and potential brain biomarkers using advanced imaging techniques. Participants will receive a Tau PET scan early in the study to measure Tau protein buildup in the brain, which is linked to neurodegeneration. The study applies advanced imaging methods including diffusion tensor imaging DTI and resting state functional MRI fMRI to explore brain connectivity and disease progression. These tools are being assessed for their ability to track changes over time in patients with AOS, with or without NFA. Throughout the study, participants will undergo repeated clinical assessments measuring speech, language, neurological, and neuropsychological function alongside imaging tests approximately 1 to 2 years after the initial scan. Researchers will compare changes in brain imaging with changes in clinical performance to better understand disease progression. Safety and eligibility will be monitored, and the study is expected to continue until mid-2028.

Longitudinal Multi-Modality Imaging in Progressive Apraxia of Speech